Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.56 |
| ▸ | CCR5 | P51681 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710585 | 0.94 | DYRK1A (0.53) | DYRK1ACCR5MAPK1SMN1; SMN2JAK2 | |
| SCHEMBL13188396 | 0.90 | DYRK1A (0.57) | DYRK1AMAPK1JAK2JAK3RAB9A | |
| SCHEMBL13187747 | 0.85 | SMN1; SMN2 (0.53) | MAPK1SMN1; SMN2RAB9ANPC1HIF1A | |
| SCHEMBL3714261 | 0.85 | DYRK1A (0.54) | DYRK1AJAK2JAK3RAB9ANPC1 | |
| SCHEMBL13188418 | 0.82 | JAK1 (0.53) | DYRK1AMAPK1SMN1; SMN2JAK2JAK3 | |
| SCHEMBL13187838 | 0.80 | RAB9A (0.53) | SMN1; SMN2RAB9ANPC1ALOX15TSHR | |
| SCHEMBL3719071 | 0.79 | MAPK1 (0.49) | MAPK1SMN1; SMN2 | |
| SCHEMBL13188492 | 0.79 | SMN1; SMN2 (0.54) | MAPK1SMN1; SMN2RAB9ANPC1HIF1A | |
| SCHEMBL13188488 | 0.78 | SMN1; SMN2 (0.53) | MAPK1SMN1; SMN2JAK2RAB9ANPC1 | |
| SCHEMBL13188330 | 0.78 | HDAC1 (0.56) | DYRK1AMAPK1SMN1; SMN2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |