Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 8/20 | 0.44 |
| ▸ | USP2 | O75604 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 11/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716537 | 0.91 | MCL1 (0.47) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL3713520 | 0.89 | GRM5 (0.46) | ALDH1A1KDM4EHPGDGAASMN1; SMN2 | |
| SCHEMBL13188547 | 0.86 | MCL1 (0.47) | ALDH1A1KDM4EMEN1KMT2AMCL1 | |
| SCHEMBL3712449 | 0.86 | GRM5 (0.44) | ALDH1A1KDM4EHPGDGAASMN1; SMN2 | |
| SCHEMBL3713434 | 0.86 | GRM5 (0.48) | ALDH1A1KDM4ESMN1; SMN2MAPTMEN1 | |
| SCHEMBL3713522 | 0.85 | GRM5 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL3710606 | 0.83 | GRM5 (0.42) | ALDH1A1KDM4EHPGDSMN1; SMN2POLB | |
| SCHEMBL3720526 | 0.83 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDGAASMN1; SMN2 | |
| SCHEMBL3710598 | 0.80 | GRM5 (0.42) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL3709730 | 0.77 | PLA2G2A (0.44) | ALDH1A1KDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |