Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | UBE2I | P63279 | 2/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720782 | 0.91 | MEN1 (0.47) | ALDH1A1KDM4EHPGDGAACASP1 | |
| SCHEMBL3713520 | 0.89 | GRM5 (0.46) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL13188838 | 0.86 | MAPT (0.40) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL3712449 | 0.86 | GRM5 (0.44) | ALDH1A1KDM4EHPGDGAACASP1 | |
| SCHEMBL3713434 | 0.86 | GRM5 (0.48) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL3713522 | 0.85 | GRM5 (0.43) | ALDH1A1KDM4EHPGDCASP1MAPT | |
| SCHEMBL3710606 | 0.83 | GRM5 (0.42) | ALDH1A1KDM4EHPGDMAPTMEN1 | |
| SCHEMBL3711244 | 0.83 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDGAACASP1 | |
| SCHEMBL3710598 | 0.80 | GRM5 (0.42) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| SCHEMBL3709730 | 0.77 | PLA2G2A (0.44) | ALDH1A1KDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |