Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714241 | 0.92 | HDAC6 (0.41) | GRM5MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3719958 | 0.89 | TSHR (0.48) | TSHRMEN1KMT2AALDH1A1HTT | |
| SCHEMBL3710834 | 0.88 | KDM4E (0.45) | TSHRGRM5MEN1KMT2AALDH1A1 | |
| SCHEMBL3714333 | 0.87 | HDAC1 (0.49) | MEN1KMT2AALDH1A1LMNARAB9A | |
| SCHEMBL13188001 | 0.87 | LMNA (0.49) | TSHRMEN1KMT2AALDH1A1HTT | |
| SCHEMBL3719635 | 0.87 | ABL1 (0.41) | — | |
| SCHEMBL3709347 | 0.87 | PTGES (0.42) | GRM5ALDH1A1LMNAACACBHIF1A | |
| SCHEMBL13188474 | 0.86 | CAMK2D (0.47) | GRM5MEN1KMT2ALMNAMAPT | |
| SCHEMBL13188263 | 0.85 | HDAC6 (0.42) | GRM5ALDH1A1LMNAHIF1A | |
| SCHEMBL3709438 | 0.85 | HIF1A (0.42) | KMT2AALDH1A1CYP11B1CYP11B2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |