Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | SQOR | Q9Y6N5 | 5/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29421461 | 0.91 | KDM4E (0.50) | KDM4EALDH1A1GAASMN1; SMN2ERBB2 | |
| SCHEMBL17116599 | 0.84 | PRMT5 (0.47) | CYP11B2SQORPRMT5WDR77METAP2 | |
| SCHEMBL1008743 | 0.83 | ALOX15 (0.44) | ALDH1A1ERBB2PRMT5WDR77TOP1 | |
| SCHEMBL2474360 | 0.82 | ESR2 (0.53) | CYP11B2PRMT5WDR77MEN1KMT2A | |
| SCHEMBL7679638 | 0.82 | ERBB2 (0.45) | KDM4EALDH1A1SMN1; SMN2ERBB2CYP11B2 | |
| SCHEMBL17116724 | 0.82 | PRMT5 (0.43) | CYP11B2SQORPRMT5WDR77METAP2 | |
| SCHEMBL22290166 | 0.82 | ERBB2 (0.45) | KDM4EALDH1A1SMN1; SMN2ERBB2CYP11B2 | |
| SCHEMBL28024938 | 0.81 | PRMT5 (0.42) | KDM4ECYP11B2SQORPRMT5WDR77 | |
| SCHEMBL18421684 | 0.80 | PRMT5 (0.41) | ALDH1A1CYP11B2PRMT5WDR77MEN1 | |
| SCHEMBL18462115 | 0.79 | PRMT5 (0.44) | KDM4EALDH1A1CYP11B2SQORPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210387968-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2021-12-16 | — | — | US | disclosed |
| US-20210387968-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2021-12-16 | — | — | US | disclosed |
| EP-3917919-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160213-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160213-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210387968-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | POLQ, POLH, POLB | KDM4E 3701/4885ALDH1A1 1242/4885GAA 445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.