SCHEMBL3712558

SCHEMBL3712558

O=CCc1c(O)cccc1Br

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.38
ERN1 O75460 2/20 0.36
TRIM24 O15164 1/20 0.34
TRIM33 Q9UPN9 1/20 0.34
CXCR2 P25025 1/20 0.33
CA1 P00915 4/20 0.32
CA2 P00918 4/20 0.32
ADAMTS4 O75173 1/20 0.32
ALDH1A1 P00352 1/20 0.32
EGFR P00533 1/20 0.32
LMNA P02545 1/20 0.32
FYN P06241 1/20 0.32
MMP2 P08253 1/20 0.32
MMP9 P14780 1/20 0.32
HPGD P15428 1/20 0.32
ALOX15 P16050 1/20 0.32
MMP8 P22894 1/20 0.32
CA6 P23280 1/20 0.32
CDK2 P24941 1/20 0.32
MMP12 P39900 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2572318 0.85 CYP2A6 (0.34) CA1CA2ALDH1A1CA6
SCHEMBL2727597 0.85 ERN1 (0.43) ERN1TRIM24TRIM33CA1CA2
Formaldehyde SCHEMBL27719025 0.81 SRD5A1 (0.41) MAOBALDH1A1LMNAHPGDHSD17B10
SCHEMBL472453 0.80 GABRA1 (0.41) MAOBALDH1A1LMNAHPGDHSD17B10
SCHEMBL30681485 0.76 EED (0.37) MAOBERN1TDP1HTTGAA
SCHEMBL2470829 0.76 ERN1 (0.42) MAOBERN1TRIM24TRIM33LMNA
SCHEMBL5954018 0.76 TRPA1 (0.45) ERN1TRIM24TRIM33CXCR2CA1
SCHEMBL1238697 0.76 TSHR (0.45) ERN1ALDH1A1LMNAHPGDHSD17B10
SCHEMBL5078599 0.76 EED (0.37) MAOBERN1TDP1HTTGAA
SCHEMBL15065955 0.74 CA2 (0.38) MAOBCXCR2CA1CA2ADAMTS4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4077324-A1 NOVEL COMPOUNDS AND THEIR USE Debiopharm International SA (CH) 2022-10-26 EP disclosed
EP-3852790-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X Forma Therapeutics, Inc. (US) 2021-07-28 EP disclosed
WO-2021123372-A1 NOVEL COMPOUNDS AND THEIR USE DEBIOPHARM INTERNATIONAL S.A. (CH) 2021-06-24 WO disclosed
WO-2020061261-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2020-03-26 WO disclosed
WO-2018075959-A1 METHODS USING HDAC11 INHIBITORS FORMA THERAPEUTICS, INC. (US) 2018-04-26 WO disclosed
EP-2398809-A1 NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE Merck Canada Inc. (CA) 2011-12-28 EP disclosed
WO-2010094120-A1 NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE MERCK FROSST CANADA LTD. (CA) 2010-08-26 WO disclosed