Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 10/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 3/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712647 | 0.86 | WNT3A (0.51) | WNT3AHDAC4DHODHHCAR2STING1 | |
| SCHEMBL29779555 | 0.86 | WNT3A (0.51) | WNT3AHDAC4DHODHHCAR2STING1 | |
| SCHEMBL11821840 | 0.76 | HDAC4 (0.50) | HDAC4DHODHKDM4EALDH1A1HCAR2 | |
| SCHEMBL7091829 | 0.76 | HDAC4 (0.50) | HDAC4DHODHKDM4EALDH1A1HCAR2 | |
| Maleic Acid SCHEMBL28002347 | 0.70 | P2RX7 (0.42) | HDAC4KDM4EALDH1A1HCAR2FTO | |
| Maleic Acid SCHEMBL28002349 | 0.70 | P2RX7 (0.42) | HDAC4KDM4EALDH1A1HCAR2FTO | |
| Maleic Acid SCHEMBL3709578 | 0.70 | TSHR (0.53) | HDAC4KDM4EALDH1A1HCAR2FTO | |
| Fumaric Acid SCHEMBL3661879 | 0.70 | TSHR (0.53) | HDAC4KDM4EALDH1A1HCAR2FTO | |
| Fumaric Acid SCHEMBL3661882 | 0.70 | TSHR (0.53) | HDAC4KDM4EALDH1A1HCAR2FTO | |
| SCHEMBL6213928 | 0.69 | DHODH (0.56) | HDAC4DHODHKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396333-A1 | TRIAZOLO [4,3-B]PYRIDAZINE DERIVATIVES AND THEIR USES FOR PROSTATE CANCER | AstraZeneca AB (SE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092371-A1 | TRIAZOLO [4,3-B] PYRIDAZINE DERIVATIVES AND THEIR USES FOR PROSTATE CANCER | ASTRAZENECA AB (SE) | 2010-08-19 | — | — | WO | disclosed |