Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 15/20 | 0.78 |
| ▸ | GSTA1 | P08263 | 9/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | HTT | P42858 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.78 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | TP53 | P04637 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | TSHR | P16473 | 1/20 | 0.78 |
| ▸ | RECQL | P46063 | 1/20 | 0.78 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.78 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.78 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.78 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | ATM | Q13315 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethacrynic Acid SCHEMBL9108011 | 0.88 | GSTP1 (1.00) | GSTP1GSTA1ALDH1A1HTTMEN1 | |
| SCHEMBL10014667 | 0.88 | GSTP1 (0.80) | GSTP1GSTA1ALDH1A1HTTMEN1 | |
| Ethacrynic Acid SCHEMBL26353 | 0.88 | GSTP1 (1.00) | GSTP1GSTA1ALDH1A1HTTMEN1 | |
| SCHEMBL10031684 | 0.88 | GSTP1 (0.80) | GSTP1GSTA1ALDH1A1HTTMEN1 | |
| Ethacrynic Acid SCHEMBL29384243 | 0.88 | GSTP1 (1.00) | GSTP1GSTA1ALDH1A1HTTMEN1 | |
| SCHEMBL3713736 | 0.88 | GSTP1 (0.80) | GSTP1GSTA1ALDH1A1HTTMEN1 | |
| SCHEMBL15285485 | 0.86 | GSTP1 (0.78) | GSTP1GSTA1ALDH1A1HTTMEN1 | |
| Ethacrynic Acid SCHEMBL2482896 | 0.86 | GSTP1 (0.97) | GSTP1GSTA1ALDH1A1HTTMEN1 | |
| Ethacrynic Acid SCHEMBL905726 | 0.86 | GSTP1 (0.97) | GSTP1GSTA1ALDH1A1HTTMEN1 | |
| Ethacrynic Acid SCHEMBL3713733 | 0.86 | GSTP1 (0.97) | GSTP1GSTA1ALDH1A1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10557853-B2 | Molecular sensor and methods of use thereof | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2020-02-11 | — | — | US | disclosed |
| US-20170307625-A1 | MOLECULAR SENSOR AND METHODS OF USE THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2017-10-26 | — | — | US | disclosed |
| US-9765019-B2 | Small-molecule-targeted protein degradation | BRANDEIS UNIVERSITY (US) | 2017-09-19 | — | — | US | disclosed |
| US-9696310-B2 | Molecular sensor and methods of use thereof | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2017-07-04 | — | — | US | disclosed |
| US-20150276753-A1 | MOLECULAR SENSOR AND METHODS OF USE THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-10-01 | — | — | US | disclosed |
| US-20130190340-A1 | Small-Molecule-Targeted Protein Degradation | BRANDEIS UNIVERSITY (US) | 2013-07-25 | — | — | US | disclosed |
| US-20130156701-A1 | METHOD OF PREPARING ETHACRYNIC AMIDE DERIVATIVES AND APPLICATION THEREOF | NATIONAL TSING HUA UNIVERSITY (TW) | 2013-06-20 | — | — | US | disclosed |
| US-20130156701-A1 | METHOD OF PREPARING ETHACRYNIC AMIDE DERIVATIVES AND APPLICATION THEREOF | NATIONAL TSING HUA UNIVERSITY (TW) | 2013-06-20 | — | — | US | disclosed |
| US-8093427-B2 | Construction and screening of solution-phase derived library of fenbufen and ethacrynic acid | NATIONAL TSING HUA UNIVERSITY (TW) | 2012-01-10 | — | — | US | disclosed |
| US-20110306668-A1 | CONSTRUCTION AND SCREENING OF SOLUTION-PHASE DERIVED LIBRARY OF FENBUFEN AND ETHACRYNIC ACID | NATIONAL TSING HUA UNIVERSITY (TW) | 2011-12-15 | — | — | US | disclosed |
| US-20110306671-A1 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | The Regents of the The University of California (US) | 2011-12-15 | — | — | US | disclosed |
| WO-2010077310-A2 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130156701-A1 | METHOD OF PREPARING ETHACRYNIC AMIDE DERIVATIVES AND APPLICATION THEREOF | FAP, ALK, PIGO | GSTP1 66/4885GSTA1 130/4885ALDH1A1 617/4885 |
| US-20150276753-A1 | MOLECULAR SENSOR AND METHODS OF USE THEREOF | MAVS, STIM1, HSPE1 | GSTP1 2603/4885GSTA1 2413/4885ALDH1A1 2649/4885 |
| US-20130190340-A1 | Small-Molecule-Targeted Protein Degradation | SMURF2, SMURF1, MDM2 | GSTP1 2946/4885GSTA1 2722/4885ALDH1A1 3772/4885 |
| US-20170307625-A1 | MOLECULAR SENSOR AND METHODS OF USE THEREOF | MAVS, STIM1, HSPE1 | GSTP1 2603/4885GSTA1 2413/4885ALDH1A1 2649/4885 |
| US-20110306671-A1 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | EPX, TNF, NFKBIA | GSTP1 492/4885GSTA1 258/4885ALDH1A1 102/4885 |
| US-20110306668-A1 | CONSTRUCTION AND SCREENING OF SOLUTION-PHASE DERIVED LIBRARY OF FENBUFEN AND ETHACRYNIC ACID | CYP4F2, ACR, CYP4F3 | GSTP1 33/4885GSTA1 78/4885ALDH1A1 48/4885 |
| US-10557853-B2 | Molecular sensor and methods of use thereof | MAVS, STIM1, HSPE1 | GSTP1 2603/4885GSTA1 2413/4885ALDH1A1 2649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.