Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | TPH1 | P17752 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660963 | 0.88 | PTGS2 (0.41) | ADORA1ADORA2APTGS1PTGS2PDE3A | |
| SCHEMBL3717801 | 0.87 | ADORA1 (0.36) | ADORA1ADORA2ATPH1ALDH1A1EGLN2 | |
| SCHEMBL3714165 | 0.86 | TPH1 (0.40) | TPH1PTGS1PTGS2PDE3ANR4A2 | |
| SCHEMBL3715648 | 0.85 | NR4A2 (0.44) | ADORA1ADORA2ATPH1PTGS1PTGS2 | |
| SCHEMBL3711503 | 0.82 | PTGS2 (0.40) | TPH1PTGS1PTGS2PDE3ANR4A2 | |
| SCHEMBL2777586 | 0.82 | TARBP2 (0.47) | PTGS1PTGS2PDE3ATHRBKDM4E | |
| SCHEMBL2776313 | 0.81 | EGLN1 (0.46) | PTGS1PTGS2PDE3ATHRBKDM4E | |
| SCHEMBL3717499 | 0.79 | ERBB2 (0.33) | ADORA1ADORA2AKDM4EALDH1A1HPGD | |
| SCHEMBL3716789 | 0.79 | TPH1 (0.35) | ADORA1ADORA2ATPH1ALDH1A1EGLN2 | |
| SCHEMBL3712146 | 0.78 | PTGS1 (0.31) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |