Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716789 | 0.90 | TPH1 (0.35) | ERBB2MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL3722940 | 0.90 | GPBAR1 (0.32) | GPBAR1CYP2D6CYP2C9CYP2C19MEN1 | |
| SCHEMBL3714390 | 0.84 | DHODH (0.36) | GPBAR1CYP2D6CYP2C9CYP2C19MEN1 | |
| SCHEMBL3717749 | 0.84 | GPBAR1 (0.38) | GPBAR1CYP2D6CYP2C9CYP2C19MEN1 | |
| SCHEMBL3717801 | 0.82 | ADORA1 (0.36) | ERBB2ADORA2AADORA1EGLN2EGLN1 | |
| SCHEMBL2775720 | 0.80 | EGLN1 (0.47) | EGLN2EGLN1 | |
| SCHEMBL3714404 | 0.79 | ADORA1 (0.39) | ADORA2AADORA1XDHEGLN2EGLN1 | |
| SCHEMBL3722988 | 0.74 | TPH1 (0.39) | GPBAR1KMT2ADHODHEGLN1 | |
| SCHEMBL3721279 | 0.74 | EGLN1 (0.39) | GPBAR1KMT2AEGLN1KDM4EALDH1A1 | |
| SCHEMBL3711503 | 0.72 | PTGS2 (0.40) | GPBAR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |