Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | TPH1 | P17752 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716789 | 0.92 | TPH1 (0.35) | ADORA1ADORA2ATPH1LMNAERBB2 | |
| SCHEMBL3714404 | 0.87 | ADORA1 (0.39) | ADORA1ADORA2ATPH1ALDH1A1EGLN1 | |
| SCHEMBL3717499 | 0.82 | ERBB2 (0.33) | ADORA1ADORA2AERBB2ALDH1A1EGLN1 | |
| SCHEMBL3721279 | 0.80 | EGLN1 (0.39) | TPH1LMNAALDH1A1EGLN1SLC26A6 | |
| SCHEMBL3722988 | 0.80 | TPH1 (0.39) | TPH1LMNAEGLN1PTGDR2SLC26A6 | |
| SCHEMBL2774182 | 0.80 | EGLN1 (0.54) | EGLN1EGLN2 | |
| SCHEMBL3712146 | 0.80 | PTGS1 (0.31) | — | |
| SCHEMBL3660963 | 0.74 | PTGS2 (0.41) | ADORA1ADORA2AALDH1A1EGLN1EGLN2 | |
| SCHEMBL3722940 | 0.73 | GPBAR1 (0.32) | — | |
| SCHEMBL2777131 | 0.72 | EGLN1 (0.54) | EGLN1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |