Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 10/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13190007 | 0.85 | SLC6A2 (0.39) | SLC6A2SLC6A4OPRM1SLC6A3ALDH1A1 | |
| SCHEMBL10613993 | 0.85 | SLC6A4 (0.50) | SLC6A2SLC6A4OPRM1SLC6A3ALDH1A1 | |
| SCHEMBL2640257 | 0.85 | SLC6A2 (0.35) | SLC6A2SLC6A4OPRM1SLC6A3 | |
| SCHEMBL4127265 | 0.84 | TSHR (0.42) | SLC6A2SLC6A4OPRM1ALDH1A1MEN1 | |
| SCHEMBL12165433 | 0.82 | SLC6A2 (0.36) | SLC6A2SLC6A4OPRM1SLC6A3 | |
| SCHEMBL1671921 | 0.81 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL12187990 | 0.81 | EGFR (0.38) | SLC6A2SLC6A4OPRM1SLC6A3ALDH1A1 | |
| SCHEMBL13594882 | 0.81 | SLC6A2 (0.38) | SLC6A2SLC6A4OPRM1SLC6A3 | |
| SCHEMBL14346106 | 0.81 | ALDH1A1 (0.33) | SLC6A2SLC6A4OPRM1SLC6A3ALDH1A1 | |
| SCHEMBL17215125 | 0.80 | SLC6A2 (0.41) | SLC6A2SLC6A4OPRM1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144517-A1 | PROCESS FOR THE PREPARATION OF CYCLOHEXANOL DERIVATIVES | EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MÜKÖDÖ (HU) | 2009-12-03 | — | — | WO | claimed |
| WO-2009084037-A2 | NOVEL PROCESS FOR PREPARATION OF O-DESMETHYLVENLAFAXINE | CALYX CHEMICALS AND PHARMACEUTICALS LTD. (IN) | 2009-07-09 | — | — | WO | claimed |
| US-20210101863-A1 | Substituted Phenethylamines with Serotoninergic and/or Norepinephrinergic Activity | ACADIA PHARMACEUTICALS INC. | 2021-04-08 | — | — | US | disclosed |
| WO-2010100520-A1 | A PROCESS FOR PREPARATION OF PHENETHYLAMINE DERIVATIVE | HIKAL LIMITED (IN) | 2010-09-10 | — | — | WO | disclosed |
| WO-2009144517-A1 | PROCESS FOR THE PREPARATION OF CYCLOHEXANOL DERIVATIVES | EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MÜKÖDÖ (HU) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009084037-A2 | NOVEL PROCESS FOR PREPARATION OF O-DESMETHYLVENLAFAXINE | CALYX CHEMICALS AND PHARMACEUTICALS LTD. (IN) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009084037-A2 | NOVEL PROCESS FOR PREPARATION OF O-DESMETHYLVENLAFAXINE | CALYX CHEMICALS AND PHARMACEUTICALS LTD. (IN) | 2009-07-09 | — | — | WO | disclosed |
| US-20090062572-A1 | Processes for the synthesis of O-desmethylvenlafaxine | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-03-05 | — | — | US | disclosed |
| US-20090062572-A1 | Processes for the synthesis of O-desmethylvenlafaxine | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-03-05 | — | — | US | disclosed |
| US-20090062572-A1 | Processes for the synthesis of O-desmethylvenlafaxine | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-03-05 | — | — | US | disclosed |
| CN-101238094-A | Process for the preparation of 1-[cyano(4-hydroxyphenyl)methyl]cyclohexanol compounds | WYETH CORP (US) | 2008-08-06 | — | — | CN | disclosed |
| WO-2008059525-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF VENLAFAXINE AND ITS ANALOGS | CALYX CHEMICALS AND PHARMACEUTICALS LTD. (IN) | 2008-05-22 | — | — | WO | disclosed |
| EP-1902015-A1 | PROCESS FOR THE PREPARATION OF 1-[CYANO (4-HYDROXYPHENYL)METHYL]CYCLOHEXANOL COMPOUNDS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2008013993-A2 | PROCESSES FOR THE SYNTHESIS OF O-DESMETHYLVENLAFAXINE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-01-31 | — | — | WO | disclosed |
| WO-2008013993-A2 | PROCESSES FOR THE SYNTHESIS OF O-DESMETHYLVENLAFAXINE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-01-31 | — | — | WO | disclosed |
| WO-2007147564-A1 | PROCESS FOR PREPARATION OF 0-DESMETHYLVENLAFAXINE AND ITS ANALOGUES | KRKA (SI) | 2007-12-27 | — | — | WO | disclosed |
| EP-1870395-A1 | Process for preparation of o-desmethylvenlafaxine and its analogue | KRKA, D.D., Novo Mesto (SI) | 2007-12-26 | — | — | EP | disclosed |
| US-20070021627-A1 | Process for the preparation of 1-[cyano(4-hydroxyphenyl)methyl]cyclohexanol compounds | WYETH | 2007-01-25 | — | — | US | disclosed |
| US-20070021627-A1 | Process for the preparation of 1-[cyano(4-hydroxyphenyl)methyl]cyclohexanol compounds | WYETH | 2007-01-25 | — | — | US | disclosed |
| WO-2007000294-A1 | PROCESS FOR THE PREPARATION OF 1-[CYANO (4-HYDROXYPHENYL)METHYL]CYCLOHEXANOL COMPOUNDS | WYETH (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062572-A1 | Processes for the synthesis of O-desmethylvenlafaxine | CYP2D6, MAOB, CYP2C9 | SLC6A2 59/4885SLC6A4 38/4885OPRM1 142/4885 |
| US-20210101863-A1 | Substituted Phenethylamines with Serotoninergic and/or Norepinephrinergic Activity | SLC6A4, HTR4, GPR34 | SLC6A2 4/4885SLC6A4 1/4885OPRM1 25/4885 |
| US-20070021627-A1 | Process for the preparation of 1-[cyano(4-hydroxyphenyl)methyl]cyclohexanol compounds | C1S, PAH, P4HA1 | SLC6A2 2779/4885SLC6A4 2185/4885OPRM1 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.