Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | HTR2C | P28335 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 4/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | CCR7 | P32248 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875491 | 0.94 | LOXL2 (0.40) | HTR2AHTR2CKCNH2DRD2MAPK1 | |
| Hydrochloric Acid SCHEMBL1164691 | 0.93 | LOXL2 (0.39) | HTR2AHTR2CKCNH2DRD2MAPK1 | |
| SCHEMBL14242842 | 0.87 | HTR2A (0.38) | HTR2AHTR2CKCNH2DRD2MAPK1 | |
| SCHEMBL12875594 | 0.81 | DRD2 (0.41) | HTR2AHTR2CKCNH2DRD2MAPK1 | |
| SCHEMBL28856967 | 0.80 | KIF11 (0.47) | KIF11 | |
| SCHEMBL3713194 | 0.79 | HTR2A (0.35) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL3710331 | 0.78 | KIF11 (0.46) | KCNH2CCR2KIF11 | |
| Hydrochloric Acid SCHEMBL29843373 | 0.78 | KIF11 (0.46) | KIF11 | |
| SCHEMBL14243216 | 0.77 | ALDH1A1 (0.39) | HTR2AHTR2CMAPK1CCR2CDK1 | |
| SCHEMBL1164896 | 0.70 | CDK1 (0.36) | DRD2MAPK1CDK1CDK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | claimed |
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |