Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 3/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713498 | 0.89 | CYP19A1 (0.39) | HIF1AEPAS1AHRALDH1A1LMNA | |
| SCHEMBL3716108 | 0.88 | LMNA (0.45) | HIF1AEPAS1HDAC6HDAC1ALDH1A1 | |
| SCHEMBL3714333 | 0.88 | HDAC1 (0.49) | HIF1AEPAS1HDAC6HDAC1ALDH1A1 | |
| SCHEMBL13188625 | 0.88 | HDAC6 (0.45) | HDAC6HDAC1ALDH1A1HDAC3HDAC2 | |
| SCHEMBL3714241 | 0.86 | HDAC6 (0.41) | HIF1AEPAS1HDAC6HDAC1FFAR1 | |
| SCHEMBL3790839 | 0.85 | HIF1A (0.36) | HIF1AEPAS1HDAC6HDAC1FFAR1 | |
| SCHEMBL3709438 | 0.85 | HIF1A (0.42) | HIF1AEPAS1HDAC6HDAC1FFAR1 | |
| SCHEMBL13188263 | 0.83 | HDAC6 (0.42) | HIF1AEPAS1HDAC6HDAC1FFAR1 | |
| SCHEMBL3711250 | 0.83 | TSHR (0.42) | HIF1AALDH1A1LMNASIRT2GRM5 | |
| SCHEMBL3709347 | 0.81 | PTGES (0.42) | HIF1AEPAS1HDAC6HDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |