Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | CDC25C | P30307 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711302 | 0.89 | RAB9A (0.49) | LMNAKMT2AMEN1HTTCDC25A | |
| SCHEMBL3714333 | 0.88 | HDAC1 (0.49) | LMNAKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL3715066 | 0.88 | HIF1A (0.37) | LMNAGRM5HIF1AEPAS1ALDH1A1 | |
| SCHEMBL13188322 | 0.87 | LMNA (0.53) | LMNAKMT2AMEN1HTTCDC25A | |
| SCHEMBL3714241 | 0.87 | HDAC6 (0.41) | LMNAKMT2AMEN1GRM5HIF1A | |
| SCHEMBL3790839 | 0.86 | HIF1A (0.36) | LMNAGRM5HIF1AEPAS1ALDH1A1 | |
| SCHEMBL3709438 | 0.86 | HIF1A (0.42) | LMNAKMT2ARAB9ANPC1HIF1A | |
| SCHEMBL13188263 | 0.84 | HDAC6 (0.42) | LMNAGRM5HIF1AEPAS1ALDH1A1 | |
| SCHEMBL3711250 | 0.84 | TSHR (0.42) | LMNAKMT2AMEN1HTTRAB9A | |
| SCHEMBL3709347 | 0.82 | PTGES (0.42) | LMNASMN1; SMN2GRM5HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |