Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 10/20 | 0.64 |
| ▸ | DDO | Q99489 | 6/20 | 0.64 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | IDE | P14735 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363456 | 0.78 | DAO (1.00) | DAODDOKDM4EALDH1A1MAPT | |
| SCHEMBL3431869 | 0.77 | DAO (0.49) | DAODDOAR | |
| SCHEMBL15690473 | 0.75 | DAO (0.65) | DAODDOKDM4EALDH1A1MAPT | |
| SCHEMBL16767849 | 0.75 | DAO (1.00) | DAODDOKDM4EALDH1A1MAPT | |
| SCHEMBL3423807 | 0.75 | DAO (1.00) | DAODDOKDM4EALDH1A1MAPT | |
| SCHEMBL3418623 | 0.74 | DAO (0.64) | DAODDOKIF11KDM4EALDH1A1 | |
| SCHEMBL1144458 | 0.74 | KDM4E (0.53) | DAOKIF11AXLKDM4EALDH1A1 | |
| SCHEMBL30310417 | 0.74 | KDM4E (0.53) | DAOKIF11AXLKDM4EALDH1A1 | |
| SCHEMBL3715319 | 0.73 | EGFR (0.44) | DAODDOKDM4EALDH1A1AR | |
| SCHEMBL3787127 | 0.73 | KIF11 (0.51) | KIF11AXLKDM4EALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058314-A1 | HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010058314-A1 | HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 2010-05-27 | — | — | WO | disclosed |