Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854918 | 0.78 | KDM4E (0.45) | PDE10AHPGDMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL2118060 | 0.78 | CA1 (0.45) | CA1LMNAHPGDSMN1; SMN2HDAC1 | |
| SCHEMBL7420604 | 0.77 | KDM4E (0.51) | PDE10ALMNAHPGDSMN1; SMN2HTT | |
| SCHEMBL7210527 | 0.76 | ALDH1A1 (0.38) | PDE10ALMNAHPGDSMN1; SMN2MTNR1A | |
| SCHEMBL590594 | 0.74 | MTNR1A (0.42) | CA1MTNR1AMTNR1BCA2 | |
| SCHEMBL3433145 | 0.74 | KMT2A (0.49) | CA1HPGDHDAC1HDAC2MEN1 | |
| SCHEMBL2944266 | 0.74 | METAP2 (0.40) | KMT2A | |
| SCHEMBL3580521 | 0.74 | MEN1 (0.48) | CA1CA12CA14LMNASMN1; SMN2 | |
| SCHEMBL7448868 | 0.73 | PDE10A (0.60) | PDE10ALMNAHPGDHDAC1HDAC2 | |
| SCHEMBL3715449 | 0.72 | PIM2 (0.44) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027108-B1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | GLAXO GROUP LTD (GB) | 2010-01-13 | — | — | EP | disclosed |
| US-20090181950-A1 | Histamine Receptor Antagonists Comprising an Azepin Core | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | US | disclosed |
| EP-2027108-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | Glaxo Group Limited (GB) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007135081-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | GLAXO GROUP LIMITED (GB) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181950-A1 | Histamine Receptor Antagonists Comprising an Azepin Core | HRH2, HRH1, HRH4 | PDE10A 2838/4885CA1 3013/4885CA12 3061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.