Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | PRKACA | P17612 | 3/20 | 0.42 |
| ▸ | CLK2 | P49760 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | PRKCG | P05129 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715657 | 0.83 | PDK4 (0.56) | DRD2MAPTLMNAPOLBPDK4 | |
| SCHEMBL3809283 | 0.82 | DRD2 (0.47) | DRD2MAPTLMNAPOLBCHEK1 | |
| SCHEMBL3809281 | 0.79 | DRD2 (0.48) | DRD2MAPTLMNAPOLBTP53 | |
| SCHEMBL4664978 | 0.77 | BTK (0.40) | DRD2MAPTLMNACHEK1MAP4K4 | |
| SCHEMBL4590003 | 0.77 | WDR5 (0.40) | MAPTPOLBCHEK1MAP4K4PIM1 | |
| SCHEMBL3226626 | 0.76 | MAPT (0.66) | DRD2MAPTLMNAPOLBTP53 | |
| SCHEMBL4665003 | 0.76 | JAK2 (0.38) | DRD2MAPTCHEK1MAP4K4PIM1 | |
| SCHEMBL4664786 | 0.75 | BTK (0.39) | DRD2MAPTCHEK1MAP4K4PIM1 | |
| Potassium Ion SCHEMBL3231230 | 0.74 | MAPT (0.64) | DRD2MAPTLMNAPOLBTP53 | |
| SCHEMBL4053840 | 0.73 | CHEK1 (0.61) | MAPTCHEK1MAP4K4PIM1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2211618-A1 | PIPERIDINYLHYDROXYETHYLPIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTORS | Glaxo Group Limited (GB) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009049113-A1 | PIPERIDINYLHYDROXYETHYLPIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-04-16 | — | — | WO | disclosed |