Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | PRKCG | P05129 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | MARK3 | P27448 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | FLT4 | P35916 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664978 | 0.88 | BTK (0.40) | BTKCHEK1MAP4K4CHEK2PRKCG | |
| SCHEMBL4665003 | 0.87 | JAK2 (0.38) | BTKCHEK1MAP4K4CHEK2PRKCG | |
| SCHEMBL4663355 | 0.86 | JAK1 (0.46) | BTKJAK1 | |
| SCHEMBL3715658 | 0.75 | DRD2 (0.49) | CHEK1MAP4K4CHEK2PRKCGCDK1 | |
| SCHEMBL4665049 | 0.74 | JAK1 (0.48) | BTKJAK1 | |
| SCHEMBL5007703 | 0.73 | JAK1 (0.47) | BTKJAK1 | |
| SCHEMBL4590003 | 0.72 | WDR5 (0.40) | BTKCHEK1MAP4K4CHEK2PRKCG | |
| SCHEMBL5302846 | 0.69 | IKBKB (0.43) | MAPTJAK2JAK1LNPEPTDP1 | |
| SCHEMBL4666734 | 0.66 | IKBKB (0.48) | BTKFLT3AURKAJAK2 | |
| SCHEMBL3226626 | 0.66 | MAPT (0.66) | MAPTHTR1ADRD2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940296-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007114848-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-11 | — | — | WO | disclosed |