Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | PRKCG | P05129 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 2/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | MARK3 | P27448 | 2/20 | 0.36 |
| ▸ | FLT4 | P35916 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL552701 | 0.84 | GABRP (0.47) | WDR5SLC6A4MAPTGABRPGABRD | |
| SCHEMBL14391466 | 0.84 | SLC6A4 (0.40) | SLC6A4MAPK1MAPTPOLBBTK | |
| SCHEMBL4665003 | 0.77 | JAK2 (0.38) | WDR5MAPK1CHEK1MAP4K4CHEK2 | |
| SCHEMBL5024842 | 0.77 | IKBKB (0.47) | FLT3AURKABTKIKBKB | |
| SCHEMBL3715658 | 0.77 | DRD2 (0.49) | WDR5MAPK1CHEK1MAP4K4CHEK2 | |
| SCHEMBL4686147 | 0.76 | TDO2 (0.52) | SLC6A4MAPK1MAPTBTKTP53 | |
| SCHEMBL4664978 | 0.74 | BTK (0.40) | WDR5MAPK1CHEK1MAP4K4CHEK2 | |
| SCHEMBL4664786 | 0.72 | BTK (0.39) | WDR5MAPK1CHEK1MAP4K4CHEK2 | |
| SCHEMBL5302846 | 0.72 | IKBKB (0.43) | MAPTMEN1IKBKBALDH1A1KMT2A | |
| SCHEMBL3989890 | 0.71 | TLR9 (0.39) | MAPK1MAPTBTKTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948187-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-30 | — | — | EP | disclosed |
| EP-1896014-A2 | CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1793826-A2 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007062318-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007005534-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-11 | — | — | WO | disclosed |
| EP-1703905-A1 | INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS IN PARTICULAR IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-27 | — | — | EP | disclosed |
| WO-2006034317-A2 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-03-30 | — | — | WO | disclosed |
| WO-2005067923-A1 | INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS IN PARTICULAR IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-28 | — | — | WO | disclosed |