Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATF4 | P18848 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2810198 | 0.89 | MAPT (0.44) | MAPTPOLBTP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL16927719 | 0.87 | MCHR1 (0.43) | MAPTPOLBSMN1; SMN2L3MBTL1MCHR1 | |
| SCHEMBL16927741 | 0.80 | MCHR1 (0.42) | MCHR1 | |
| SCHEMBL16927755 | 0.78 | MAPT (0.39) | MAPTPOLBSMN1; SMN2MCHR1LMNA | |
| SCHEMBL2807759 | 0.77 | MCHR1 (0.44) | MAPTPOLBSMN1; SMN2L3MBTL1MCHR1 | |
| SCHEMBL16927728 | 0.75 | FAAH (0.34) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL2809666 | 0.75 | LMNA (0.42) | MAPTTP53SMN1; SMN2L3MBTL1MCHR1 | |
| SCHEMBL2809050 | 0.74 | ENPP2 (0.43) | MAPTSMN1; SMN2L3MBTL1LMNAHPGD | |
| SCHEMBL16938617 | 0.74 | MAPT (0.35) | MAPTPOLBTP53LMNA | |
| SCHEMBL16927758 | 0.72 | NFKB1 (0.40) | MAPTHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209777-B1 | THIAZOL DERIVATIVES FOR TREATING CANCER | MERCK PATENT GMBH (DE) | 2015-07-29 | — | — | EP | claimed |
| EP-2209777-A2 | THIAZOL DERIVATIVES FOR TREATING CANCER | Merck Patent GmbH (DE) | 2010-07-28 | — | — | EP | claimed |
| WO-2009046842-A2 | THIAZOL DERIVATIVES FOR TREATING CANCER | MERCK PATENT GMBH (DE) | 2009-04-16 | — | — | WO | claimed |
| EP-2209777-B1 | THIAZOL DERIVATIVES FOR TREATING CANCER | MERCK PATENT GMBH (DE) | 2015-07-29 | — | — | EP | disclosed |