Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11926407 | 0.82 | CASP7 (0.46) | CASP7CASP6SIGMAR1ALDH1A1KDM4E | |
| SCHEMBL4597642 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL3711915 | 0.81 | PIK3CA (0.53) | SMN1; SMN2LMNAALDH1A1MAPK1MAPT | |
| SCHEMBL3714240 | 0.81 | AURKA (0.54) | SMN1; SMN2LMNAALDH1A1KDM4ETP53 | |
| SCHEMBL11926408 | 0.80 | KDM4E (0.45) | SMN1; SMN2ALDH1A1KDM4ETP53TSHR | |
| SCHEMBL23213138 | 0.77 | POLB (0.53) | SMN1; SMN2ALDH1A1KDM4ETSHRMAPT | |
| SCHEMBL3712432 | 0.77 | ACACB (0.47) | SMN1; SMN2MAPK1 | |
| SCHEMBL762872 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDMAPTNPC1 | |
| SCHEMBL3117274 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2CASP7CASP6SIGMAR1ALDH1A1 | |
| SCHEMBL15720845 | 0.76 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1KDM4ETP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |