Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 8/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431643 | 0.87 | P2RY12 (0.71) | P2RY12MAPTTRPV1 | |
| SCHEMBL13931689 | 0.86 | TRPV1 (0.72) | ALDH1A1LMNAPOLBMAPTHPGD | |
| SCHEMBL3710357 | 0.83 | TRPV1 (0.74) | TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL3709422 | 0.83 | LMNA (0.53) | ALDH1A1LMNAPOLBMAPTTRPV1 | |
| SCHEMBL3790379 | 0.80 | P2RY12 (0.79) | P2RY12 | |
| SCHEMBL3707073 | 0.80 | MAPT (0.52) | ALDH1A1LMNAPOLBMAPTTRPV1 | |
| SCHEMBL3785663 | 0.79 | MAPT (0.67) | ALDH1A1LMNAPOLBMAPTTRPV1 | |
| SCHEMBL3710143 | 0.78 | SMN1; SMN2 (0.65) | ALDH1A1LMNAPOLBMAPTTRPV1 | |
| SCHEMBL6433813 | 0.76 | CNR2 (0.71) | P2RY12ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL18362064 | 0.75 | PHGDH (0.52) | P2RY12ALDH1A1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010092342-A1 | ORGANOSILICON COMPOUNDS AND THEIR USE AS THE MODULATORS OF THE TRPV1 RECEPTOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-19 | — | — | WO | disclosed |