Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PANK3 | Q9H999 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16707641 | 0.85 | HCAR2 (0.72) | MAPTNPSR1ALDH1A1LMNAHCAR2 | |
| SCHEMBL3710143 | 0.81 | SMN1; SMN2 (0.65) | MAPTNPSR1ALDH1A1LMNATRPV1 | |
| SCHEMBL16707625 | 0.81 | MAPT (0.74) | MAPTNPSR1ALDH1A1LMNAHCAR2 | |
| SCHEMBL3709422 | 0.80 | LMNA (0.53) | MAPTNPSR1ALDH1A1LMNAKDM4E | |
| SCHEMBL17029145 | 0.79 | LMNA (0.76) | MAPTNPSR1ALDH1A1LMNAHCAR2 | |
| SCHEMBL3716459 | 0.79 | P2RY12 (0.60) | MAPTALDH1A1LMNATRPV1POLB | |
| SCHEMBL3714314 | 0.79 | TRPV1 (0.60) | NPSR1ALDH1A1LMNATRPV1SMN1; SMN2 | |
| SCHEMBL3707073 | 0.79 | MAPT (0.52) | MAPTNPSR1ALDH1A1LMNAKDM4E | |
| SCHEMBL3785601 | 0.79 | TRPV1 (0.72) | MAPTALDH1A1LMNAKDM4ETRPV1 | |
| SCHEMBL3710357 | 0.78 | TRPV1 (0.74) | TRPV1TRPA1KCNH2TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010092342-A1 | ORGANOSILICON COMPOUNDS AND THEIR USE AS THE MODULATORS OF THE TRPV1 RECEPTOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-19 | — | — | WO | disclosed |