Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RBP4 | P02753 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709422 | 0.92 | LMNA (0.53) | MAPTSMN1; SMN2LMNATP53GAA | |
| SCHEMBL3710143 | 0.87 | SMN1; SMN2 (0.65) | MAPTSMN1; SMN2LMNAGAAMAPK1 | |
| SCHEMBL3714314 | 0.81 | TRPV1 (0.60) | SMN1; SMN2LMNAGAAMAPK1TRPV1 | |
| SCHEMBL3716459 | 0.80 | P2RY12 (0.60) | MAPTLMNATRPV1POLBALDH1A1 | |
| SCHEMBL3785663 | 0.79 | MAPT (0.67) | MAPTSMN1; SMN2LMNATP53GAA | |
| SCHEMBL13234941 | 0.77 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAGAAMAPK1TRPV1 | |
| SCHEMBL3713332 | 0.76 | MEN1 (0.59) | MAPTSMN1; SMN2GAATRPV1POLB | |
| SCHEMBL3716149 | 0.76 | POLB (0.75) | MAPTSMN1; SMN2TP53MAPK1TRPV1 | |
| SCHEMBL3710357 | 0.76 | TRPV1 (0.74) | TRPV1 | |
| SCHEMBL3781732 | 0.75 | CA12 (0.71) | MAPTSMN1; SMN2LMNAGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010092342-A1 | ORGANOSILICON COMPOUNDS AND THEIR USE AS THE MODULATORS OF THE TRPV1 RECEPTOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-19 | — | — | WO | disclosed |