Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211524 | 1.00 | AKR1C3 (0.56) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| SCHEMBL2914673 | 1.00 | AKR1C3 (0.56) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| Hydrochloric Acid SCHEMBL6818657 | 0.98 | AKR1C3 (0.54) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| SCHEMBL8516515 | 0.92 | AKR1C3 (0.48) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| SCHEMBL7074200 | 0.87 | TP53 (0.66) | AKR1C3AKR1C1TP53HTTTSHR | |
| SCHEMBL7074203 | 0.87 | TP53 (0.66) | AKR1C3AKR1C1TP53HTTTSHR | |
| SCHEMBL11179955 | 0.86 | AKR1C3 (0.50) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| SCHEMBL11179967 | 0.86 | AKR1C3 (0.50) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| SCHEMBL19712515 | 0.85 | ALDH1A1 (0.46) | AKR1C3AKR1C1CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL19712514 | 0.85 | ALDH1A1 (0.46) | AKR1C3AKR1C1CYP2C9CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274633-A2 | PAIN RELIEF COMPOUNDS | UNIVERSITÉ CLERMONT AUVERGNE (FR) | 2015-10-01 | — | — | US | disclosed |
| US-20150038466-A1 | PAIN RELIEF COMPOUNDS | ECOLE NATIONALE SUPERIEURE DE CHIMIE DE CLERMONT FERRAND (FR) | 2015-02-05 | — | — | US | disclosed |
| WO-2010112092-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULARY DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-10-07 | — | — | WO | disclosed |
| CN-100445285-C | Nicotinic acetylcholine receptor ligands | ASTRAZENECA AB (SE) | 2008-12-24 | — | — | CN | disclosed |
| US-20070244097-A1 | Nicotinic AcetylcholineReceptor Ligands | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | disclosed |
| CN-1902204-A | Nicotinic acetylcholine receptor ligands | ASTRAZENECA AB (SE) | 2007-01-24 | — | — | CN | disclosed |
| EP-1699802-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061511-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038466-A1 | PAIN RELIEF COMPOUNDS | OPRL1, OPRK1, TRPV1 | AKR1C3 1085/4885AKR1C1 1516/4885CYP2C9 3721/4885 |
| US-20150274633-A2 | PAIN RELIEF COMPOUNDS | OPRL1, OPRK1, TRPV1 | AKR1C3 1085/4885AKR1C1 1516/4885CYP2C9 3721/4885 |
| US-20070244097-A1 | Nicotinic AcetylcholineReceptor Ligands | CHRNG, CHRNE, CHRNA1 | AKR1C3 1677/4885AKR1C1 1682/4885CYP2C9 752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.