SCHEMBL3716769

SCHEMBL3716769

C[CH]c1cccc(Cl)c1C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
MAPT P10636 2/20 0.36
RAPGEF4 Q8WZA2 1/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2A6 P11509 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
LMNA P02545 3/20 0.35
POLB P06746 1/20 0.35
IDO1 P14902 1/20 0.35
TSHR P16473 2/20 0.35
CYP3A4 P08684 2/20 0.35
PIK3CA P42336 1/20 0.35
RECQL P46063 1/20 0.33
CHAT P28329 1/20 0.33
USP2 O75604 1/20 0.33
MT-CO2 P00403 1/20 0.33
TTR P02766 1/20 0.33
PLA2G1B P04054 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19879746 0.82 ALDH1A1 (0.45) ALDH1A1MAPTRAPGEF4CYP1A2CYP2A6
SCHEMBL19140150 0.82 ALDH1A1 (0.45) ALDH1A1MAPTRAPGEF4CYP1A2CYP2A6
SCHEMBL9442667 0.82 ALDH1A1 (0.45) ALDH1A1MAPTRAPGEF4CYP1A2CYP2A6
SCHEMBL1532661 0.79 ALDH1A1 (0.60) ALDH1A1MAPTRAPGEF4CYP1A2CYP2A6
SCHEMBL29952946 0.79 ALDH1A1 (0.50) ALDH1A1MAPTMEN1KMT2ATDP1
SCHEMBL16955594 0.79 ALDH1A1 (0.46) ALDH1A1MAPTRAPGEF4CYP1A2CYP2A6
SCHEMBL3409591 0.79 ALDH1A1 (0.50) ALDH1A1MAPTMEN1KMT2ATDP1
SCHEMBL1547373 0.78 L3MBTL1 (0.46) ALDH1A1CYP1A2CYP2A6MEN1KMT2A
SCHEMBL97512 0.77
SCHEMBL112040 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010131147-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO claimed
WO-2010131145-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO claimed
WO-2010131146-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO claimed
CN-104703980-A Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives ACTELION PHARMACEUTICALS LTD 2015-06-10 CN disclosed
WO-2010131147-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed
WO-2010131145-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed
WO-2010131146-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed
EP-0340709-A1 (3-Chloro-methyl phenyl)ethyl amines, processes for their production and their use BASF Aktiengesellschaft (DE) 1989-11-08 EP disclosed