Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722047 | 0.92 | GLA (0.42) | GLASMN1; SMN2CYP3A4TSHRCYP1A2 | |
| SCHEMBL3726083 | 0.91 | GLA (0.39) | GLASMN1; SMN2CYP3A4TSHRCYP1A2 | |
| SCHEMBL3720106 | 0.87 | SMN1; SMN2 (0.49) | GLASMN1; SMN2CYP3A4TSHRCYP1A2 | |
| SCHEMBL3718486 | 0.86 | TSHR (0.37) | GLASMN1; SMN2CYP3A4TSHRCYP1A2 | |
| SCHEMBL3721858 | 0.86 | GLA (0.43) | GLASMN1; SMN2CYP3A4TSHRCYP1A2 | |
| SCHEMBL3721410 | 0.85 | MAPT (0.36) | SMN1; SMN2KDM4EATMLMNAKMT2A | |
| SCHEMBL3719459 | 0.83 | PARP10 (0.37) | — | |
| SCHEMBL3722996 | 0.83 | MTNR1A (0.53) | SMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL3718570 | 0.83 | TSHR (0.38) | GLASMN1; SMN2CYP3A4TSHRCYP1A2 | |
| SCHEMBL3719435 | 0.82 | TLR8 (0.37) | GLASMN1; SMN2CYP3A4TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |