Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721868 | 0.83 | PDE4B (0.48) | PDE4BCYP2A6MAPK14ALDH1A1HPGD | |
| SCHEMBL3717153 | 0.82 | PDE4B (0.43) | PDE4BCYP2A6MAPK14ALDH1A1HPGD | |
| SCHEMBL3720071 | 0.82 | PDE4B (0.49) | PDE4BCYP2A6MAPK14HPGDKDM4E | |
| SCHEMBL3720271 | 0.82 | PDE4B (0.42) | PDE4BCYP2A6MAPK14ALDH1A1HPGD | |
| SCHEMBL3720755 | 0.81 | PDE4B (0.46) | PDE4BALDH1A1SMN1; SMN2PPARGGAA | |
| SCHEMBL3719225 | 0.80 | PDE4B (0.46) | PDE4BCYP2A6MAPK14ALDH1A1SMN1; SMN2 | |
| SCHEMBL3724295 | 0.80 | PDE4B (0.46) | PDE4BALDH1A1PPARGGAAPOLB | |
| SCHEMBL3720433 | 0.79 | SCN7A (0.49) | PDE4BSMN1; SMN2PPARGKMT2A | |
| SCHEMBL3726370 | 0.79 | PDE4B (0.47) | PDE4BALDH1A1SMN1; SMN2 | |
| SCHEMBL3726792 | 0.79 | PDE4B (0.45) | PDE4BALDH1A1KDM4ESMN1; SMN2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |