Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718047 | 0.87 | SCN9A (0.58) | SCN9ALMNAALDH1A1POLBHTT | |
| SCHEMBL3717784 | 0.82 | ACP1 (0.47) | SCN9AMAPK1LMNAALDH1A1GLA | |
| SCHEMBL3722028 | 0.80 | GRM2 (0.45) | SCN9AMAPK1LMNAALDH1A1KMT2A | |
| SCHEMBL3723259 | 0.77 | PTGS1 (0.48) | SCN9AALDH1A1NPC1RAB9A | |
| SCHEMBL3720910 | 0.76 | LMNA (0.78) | SCN9AMAPK1LMNAALDH1A1GLA | |
| SCHEMBL787531 | 0.74 | SCN9A (1.00) | SCN9A | |
| SCHEMBL29421433 | 0.74 | SCN9A (1.00) | SCN9A | |
| SCHEMBL3727320 | 0.74 | SCN9A (0.43) | SCN9ALMNAALDH1A1GLAHTT | |
| SCHEMBL13187836 | 0.73 | WNT1 (0.42) | SCN9ALMNAALDH1A1HTTKMT2A | |
| SCHEMBL3720301 | 0.72 | KMT2A (0.43) | KMT2APIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |