Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718051 | 0.86 | ABL1 (0.49) | ACP1KMT2AMEN1MKNK1LMNA | |
| SCHEMBL3717779 | 0.82 | SCN9A (0.58) | ACP1KMT2AMEN1MKNK1MAPK1 | |
| SCHEMBL3722029 | 0.78 | L3MBTL1 (0.44) | KMT2AMEN1MAPK1LMNARAB9A | |
| SCHEMBL3720912 | 0.76 | MAPT (0.49) | KMT2AMEN1MAPK1LMNANPC1 | |
| SCHEMBL3723261 | 0.76 | PTGS1 (0.48) | KMT2AMEN1MAPK1LMNANPC1 | |
| SCHEMBL3727322 | 0.72 | AGTR1 (0.43) | LMNAACHEALDH1A1 | |
| SCHEMBL3720119 | 0.71 | ACP1 (0.44) | ACP1LMNACYP1A2ALDH1A1 | |
| SCHEMBL13312433 | 0.71 | ACP1 (0.61) | ACP1KMT2AMEN1LMNANPC1 | |
| SCHEMBL3720305 | 0.70 | PIK3CA (0.43) | KMT2ACNR1 | |
| SCHEMBL3727142 | 0.70 | AGTR1 (0.43) | KMT2AMEN1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |