Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.50 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535637 | 0.83 | KDM4C (0.58) | KDM4CKDM4DNAMPTKDM6BKDM4E | |
| SCHEMBL933049 | 0.83 | KDM4C (0.46) | KDM4CKDM4DNAMPTRXFP1METAP1 | |
| SCHEMBL3717882 | 0.78 | METAP1 (0.58) | RXFP1KMT2AMETAP1TSHRBRD9 | |
| SCHEMBL18126653 | 0.78 | KDM4C (0.52) | KDM4CKDM4DNAMPTKMT2APDE5A | |
| SCHEMBL30127947 | 0.78 | MCL1 (0.61) | KMT2ATSHR | |
| SCHEMBL18088829 | 0.78 | MCL1 (0.61) | KMT2ATSHR | |
| SCHEMBL222446 | 0.77 | RXFP1 (0.55) | RXFP1KMT2ABRD9KDM4E | |
| SCHEMBL29702265 | 0.77 | RXFP1 (0.55) | RXFP1KMT2ABRD9KDM4E | |
| SCHEMBL18522430 | 0.77 | NAMPT (0.50) | KDM4CNAMPTMETAP1 | |
| SCHEMBL2880191 | 0.77 | LMNA (0.54) | NAMPTRXFP1KMT2AMETAP1BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220042-A1 | NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES | 4SC AG (DE) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009063054-A1 | NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES | 4SC AG (DE) | 2009-05-22 | — | — | WO | disclosed |