Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 9/20 | 0.40 |
| ▸ | HTR6 | P50406 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 5/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3718488 | 0.99 | HTR7 (0.39) | HTR7HTR6HTR1AHTR2AHTR5A | |
| Hydrochloric Acid SCHEMBL3714229 | 0.81 | HSP90AA1 (0.37) | HTR7HTR6HTR1AHTR2AHTR5A | |
| Hydrochloric Acid SCHEMBL3714216 | 0.81 | HSP90AA1 (0.37) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL3735764 | 0.79 | CHRNB2 (0.34) | HTR7HTR6HTR1AHTR2BPDE10A | |
| SCHEMBL3735648 | 0.79 | HTR6 (0.38) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL3724157 | 0.79 | HTR6 (0.38) | HTR7HTR6HTR1AHTR2AHTR5A | |
| Hydrochloric Acid SCHEMBL3722421 | 0.78 | PDE10A (0.33) | HTR7HTR6HTR1AHTR2BPDE10A | |
| Hydrochloric Acid SCHEMBL3736652 | 0.78 | HTR6 (0.38) | HTR7HTR6HTR1AHTR2AHTR5A | |
| Hydrochloric Acid SCHEMBL3736648 | 0.78 | HTR6 (0.38) | HTR7HTR6HTR1AHTR2AHTR5A | |
| SCHEMBL3723414 | 0.75 | ROCK1 (0.44) | HTR7HTR6HTR1AHTR2AHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372842-B2 | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2242757-B1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-11-04 | — | — | US | disclosed |
| EP-2242757-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009089359-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | CHEK2, CHEK1, BUB1B | HTR7 3955/4885HTR6 4093/4885HTR1A 3899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.