Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.41 |
| ▸ | GPR39 | O43194 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713554 | 0.85 | OPRM1 (0.37) | SLC6A3SLC6A4SLC6A2HTR2AOPRK1 | |
| SCHEMBL3712760 | 0.83 | SLC6A3 (0.41) | SLC6A3SLC6A4SLC6A2OPRK1KCNH2 | |
| SCHEMBL3707243 | 0.83 | OPRM1 (0.49) | HTR2AOPRK1 | |
| SCHEMBL3706773 | 0.82 | SLC6A4 (0.49) | SLC6A3SLC6A4SLC6A2KCNH2 | |
| SCHEMBL3707150 | 0.81 | SLC6A3 (0.47) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL3718146 | 0.81 | OPRM1 (0.49) | SLC6A3SLC6A4 | |
| SCHEMBL3663027 | 0.80 | SLC6A3 (0.56) | SLC6A3SLC6A4SLC6A2HDAC4OPRK1 | |
| SCHEMBL3712314 | 0.80 | SLC6A3 (0.46) | SLC6A3SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL27754809 | 0.79 | SLC6A3 (0.54) | SLC6A3SLC6A4SLC6A2HDAC4OPRK1 | |
| SCHEMBL2793612 | 0.78 | OPRM1 (0.48) | DRD2SLC6A3SLC6A4SLC6A2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391603-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086251-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-05 | — | — | WO | disclosed |