Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.31 |
| ▸ | CHRNG | P07510 | 1/20 | 0.31 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718210 | 0.85 | DRD2 (0.42) | SLC6A2SLC6A3SLC6A4KCNH2OPRK1 | |
| SCHEMBL3712760 | 0.85 | SLC6A3 (0.41) | OPRM1SLC6A2SLC6A3SLC6A4KCNH2 | |
| SCHEMBL3707243 | 0.84 | OPRM1 (0.49) | OPRM1OPRL1OPRK1HTR2ASLC6A9 | |
| SCHEMBL3718146 | 0.82 | OPRM1 (0.49) | OPRM1SLC6A3SLC6A4OPRL1SLC6A9 | |
| SCHEMBL8353549 | 0.81 | OPRM1 (0.43) | OPRM1OPRL1OPRK1HDAC3HDAC1 | |
| SCHEMBL8353019 | 0.81 | OPRM1 (0.43) | OPRM1OPRL1OPRK1HDAC3HDAC1 | |
| SCHEMBL3709523 | 0.79 | HDAC3 (0.39) | SLC6A2SLC6A3SLC6A4SLC6A9HDAC3 | |
| SCHEMBL3712314 | 0.78 | SLC6A3 (0.46) | SLC6A2SLC6A3SLC6A4SLC6A9HDAC3 | |
| SCHEMBL8351053 | 0.77 | OPRM1 (0.50) | OPRM1OPRL1OPRK1HDAC3HDAC1 | |
| SCHEMBL3705259 | 0.77 | CTSD (0.37) | OPRM1SLC6A2SLC6A3SLC6A4OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391603-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086251-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-05 | — | — | WO | disclosed |