Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592999 | 0.87 | P2RX7 (0.40) | NPSR1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL8946381 | 0.87 | NPSR1 (0.41) | NPSR1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL27616306 | 0.83 | NPSR1 (0.38) | NPSR1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL10855054 | 0.80 | NPSR1 (0.50) | NPSR1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL28268679 | 0.80 | ALDH1A1 (0.56) | NPSR1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL11963737 | 0.79 | KMT2A (0.37) | NPSR1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL16964280 | 0.79 | KMT2A (0.41) | NPSR1KMT2AKDM4EHTTATM | |
| SCHEMBL26616179 | 0.79 | TNKS (0.31) | TNKSPARP1TNKS2P2RX7 | |
| SCHEMBL25420411 | 0.78 | RAB9A (0.46) | NPSR1KMT2AKDM4ENPC1POLB | |
| SCHEMBL17459987 | 0.77 | NPSR1 (0.54) | NPSR1KMT2AKDM4EHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212333-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | Wyeth LLC (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052145-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2009-04-23 | — | — | WO | disclosed |