Sugi Predict

Sugi Predict / Compounds / SCHEMBL3719012

SCHEMBL3719012

SCHEMBL3719012

COC(=O)c1cc(N)cc(F)c1Br

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 5/20 0.45
▸ KDM4E B2RXH2 7/20 0.42
▸ ALDH1A1 P00352 5/20 0.41
▸ HSD17B10 Q99714 3/20 0.41
▸ MAPT P10636 2/20 0.41
▸ HPGD P15428 2/20 0.41
▸ GLA P06280 2/20 0.41
▸ CASP1 P29466 1/20 0.41
▸ CASP7 P55210 1/20 0.41
▸ ATM Q13315 1/20 0.41
▸ CFTR P13569 3/20 0.41
▸ ABL1 P00519 1/20 0.40
▸ SOS1 Q07889 1/20 0.40
▸ TSHR P16473 3/20 0.40
▸ LMNA P02545 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ ALOX15 P16050 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ NQO2 P16083 2/20 0.38
▸ KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3726666 0.82 GAA (0.47) GAAKDM4EALDH1A1HSD17B10MAPT
SCHEMBL28406632 0.82 CES2 (0.42) GAAKDM4EALDH1A1MAPTSOS1
SCHEMBL6119252 0.82 SOS1 (0.42) GAAKDM4EHSD17B10MAPTSOS1
SCHEMBL20299060 0.82 ALDH1A1 (0.45) GAAKDM4EALDH1A1HSD17B10MAPT
SCHEMBL2525608 0.81 GAA (0.46) GAAKDM4EALDH1A1HSD17B10MAPT
SCHEMBL9618217 0.81 GAA (0.46) GAAKDM4EALDH1A1HSD17B10MAPT
SCHEMBL29608598 0.81 GAA (0.46) GAAKDM4EALDH1A1HSD17B10MAPT
SCHEMBL25243956 0.79 SOS1 (0.47) GAAKDM4EALDH1A1HSD17B10MAPT
SCHEMBL3722864 0.79 NQO2 (0.51) GAAKDM4EALDH1A1HSD17B10MAPT
SCHEMBL3723166 0.79 ABL1 (0.47) GAAKDM4EALDH1A1HSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260008791-A1 CHEMICAL COMPOUNDS BORAH INC (US) 2026-01-08 — — US disclosed
US-12358932-B2 Chemical compounds BORAH, INC. (US) 2025-07-15 — — US disclosed
US-12240825-B2 Oxexin 1 receptor antagonists NXERA PHARMA UK LIMITED (GB) 2025-03-04 — — US disclosed
US-20240368196-A1 CHEMICAL COMPOUNDS BORAH, INC. 2024-11-07 — — US disclosed
CN-114341145-B Chemical compound 博拉公司 2024-08-16 — — CN disclosed
CN-117242080-A Boron-containing pyrazole compounds, compositions comprising the same, methods and uses thereof 勃林格殷格翰动物保健美国公司 2023-12-15 — — CN disclosed
US-11827657-B2 Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof Boehringer Ingelheim Animal Health USA Inc. (US) 2023-11-28 — — US disclosed
US-11827657-B2 Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof Boehringer Ingelheim Animal Health USA Inc. (US) 2023-11-28 — — US disclosed
EP-4263559-A1 BORON CONTAINING PYRAZOLE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF Boehringer Ingelheim Animal Health USA Inc. (US) 2023-10-25 — — EP disclosed
US-20220194965-A1 BORON CONTAINING PYRAZOLE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF BORAH, INC. 2022-06-23 — — US disclosed
EP-3994142-A1 CHEMICAL COMPOUNDS Borah, Inc. (US) 2022-05-11 — — EP disclosed
CN-114341145-A Chemical compound 博拉公司 2022-04-12 — — CN disclosed
US-20220098165-A1 OXEXIN 1 RECEPTOR ANTAGONISTS NXERA PHARMA UK LIMITED (GB) 2022-03-31 — — US disclosed
WO-2021003501-A1 CHEMICAL COMPOUNDS Boragen, Inc. (US) 2021-01-07 — — WO disclosed
WO-2021003501-A1 CHEMICAL COMPOUNDS Boragen, Inc. (US) 2021-01-07 — — WO disclosed
WO-2020157474-A1 OREXIN 1 RECEPTOR ANTAGONISTS HEPTARES THERAPEUTICS LIMITED (GB) 2020-08-06 — — WO disclosed
WO-2020157474-A1 OREXIN 1 RECEPTOR ANTAGONISTS HEPTARES THERAPEUTICS LIMITED (GB) 2020-08-06 — — WO disclosed
WO-2014075387-A1 DIARYL HYDANTOIN DERIVATIVE, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF 上海医药集团股份有限公司 (CN) 2014-05-22 — — WO disclosed
WO-2010133312-A1 HALOGEN-SUBSTITUTED COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-11-25 — — WO disclosed
WO-2010133312-A1 HALOGEN-SUBSTITUTED COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-11-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008791-A1 CHEMICAL COMPOUNDS JAK3, JAK2, JAK1 GAA 2124/4885KDM4E 845/4885ALDH1A1 2401/4885
US-11827657-B2 Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof JAK3, JAK1, JAK2 GAA 2618/4885KDM4E 1548/4885ALDH1A1 3977/4885
US-20220098165-A1 OXEXIN 1 RECEPTOR ANTAGONISTS HCRTR1, HCRTR2, OXTR GAA 3739/4885KDM4E 1658/4885ALDH1A1 1901/4885
US-20220194965-A1 BORON CONTAINING PYRAZOLE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF JAK3, JAK1, JAK2 GAA 2618/4885KDM4E 1548/4885ALDH1A1 3977/4885
US-12240825-B2 Oxexin 1 receptor antagonists HCRTR1, HCRTR2, OXTR GAA 3739/4885KDM4E 1658/4885ALDH1A1 1901/4885
US-20240368196-A1 CHEMICAL COMPOUNDS PDE4A, PDE4B, SYK GAA 880/4885KDM4E 364/4885ALDH1A1 2613/4885
US-12358932-B2 Chemical compounds PDE4A, PDE4B, SYK GAA 880/4885KDM4E 364/4885ALDH1A1 2613/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.