Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3277951 | 0.78 | APP (0.44) | TSHRLMNAMAPTALDH1A1TDP1 | |
| SCHEMBL5096848 | 0.77 | ALDH1A1 (0.47) | TSHRLMNAPOLBCYP19A1MAPT | |
| SCHEMBL6373056 | 0.76 | TSHR (0.53) | TSHRLMNAPOLBCES2CES1 | |
| SCHEMBL10477420 | 0.74 | ALDH1A1 (0.44) | TSHRLMNACYP19A1CES2CES1 | |
| SCHEMBL11385468 | 0.74 | POLB (0.46) | TSHRLMNAPOLBCYP19A1MAPT | |
| SCHEMBL5461460 | 0.74 | GABRP (0.46) | TSHRLMNAPOLBCYP19A1CES2 | |
| SCHEMBL14880550 | 0.74 | ALDH1A1 (0.44) | TSHRLMNAPOLBMAPTALDH1A1 | |
| SCHEMBL10577172 | 0.74 | HSPB1 (0.42) | TSHRLMNAPOLBCYP19A1MAPT | |
| SCHEMBL6321027 | 0.74 | ACHE (0.50) | TSHRLMNAPOLBMAPTALDH1A1 | |
| SCHEMBL7367581 | 0.73 | CHEK1 (0.47) | ERN1TSHRLMNAPOLBCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135424-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-11-25 | — | — | WO | disclosed |