Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718715 | 0.88 | TSHR (0.45) | TSHRGAADAOTERTALDH1A1 | |
| SCHEMBL13401695 | 0.77 | SMN1; SMN2 (0.42) | TSHRLMNACYP2C19ALDH1A1HPGD | |
| SCHEMBL7403411 | 0.74 | ALOX15 (0.45) | TSHRGAADAOLMNACYP2C19 | |
| SCHEMBL9715396 | 0.72 | NFKB1 (0.44) | TSHRGAADAOLMNACYP2C19 | |
| SCHEMBL3797821 | 0.70 | ALDH1A1 (0.59) | GAAALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL26948701 | 0.69 | ALOX15 (0.40) | TSHRGAALMNAALDH1A1MAPT | |
| SCHEMBL3793592 | 0.67 | SMN1; SMN2 (0.48) | TSHRGAALMNACYP2C19ALDH1A1 | |
| SCHEMBL739228 | 0.66 | HTR7 (0.73) | TSHRLMNAALDH1A1HPGDMAPT | |
| Hydrochloric Acid SCHEMBL11439571 | 0.65 | SMN1; SMN2 (0.47) | TSHRGAALMNACYP2C19ALDH1A1 | |
| Pyromellitic Acid SCHEMBL11649085 | 0.65 | ALDH1A1 (0.58) | LMNACYP2C19ALDH1A1GLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |