Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15576812 | 0.89 | NPY5R (0.46) | MEN1KMT2ABRAFPTGS2SLC5A1 | |
| SCHEMBL1075033 | 0.88 | MMP2 (0.47) | LMNABRAFPTGS2SLC5A1PTGS1 | |
| SCHEMBL15474346 | 0.80 | HDAC1 (0.43) | LMNAMAPTMGLLPTGS2SLC5A1 | |
| SCHEMBL15472788 | 0.80 | MALT1 (0.46) | LMNAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12418162 | 0.79 | PTGS2 (0.66) | MAPTMEN1KMT2ASMN1; SMN2MGLL | |
| SCHEMBL2192750 | 0.76 | PTGS2 (0.64) | LMNAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL976450 | 0.74 | CNR1 (0.54) | MEN1KMT2AFAAHMGLLPTGS2 | |
| SCHEMBL5739149 | 0.73 | ALDH1A1 (0.66) | LMNAMAPTMEN1KMT2AGAA | |
| SCHEMBL2192072 | 0.72 | FAAH (0.57) | MAPTTP53MEN1KMT2AFAAH | |
| SCHEMBL1764964 | 0.72 | FAAH (0.53) | LMNAMAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217588-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009055917-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-05-07 | — | — | WO | disclosed |