Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719024 | 0.93 | HCAR3 (0.61) | HCAR3MAPTPKMPOLBALDH1A1 | |
| SCHEMBL11877200 | 0.90 | ALDH1A1 (0.57) | HCAR3MAPTPKMPOLBALDH1A1 | |
| SCHEMBL11878741 | 0.87 | HCAR3 (0.55) | HCAR3MAPTPOLBALDH1A1NPSR1 | |
| SCHEMBL5591726 | 0.84 | ALDH1A1 (0.50) | HCAR3MAPTPKMPOLBALDH1A1 | |
| SCHEMBL3721854 | 0.83 | MAPT (0.60) | HCAR3MAPTPKMPOLBALDH1A1 | |
| SCHEMBL3720311 | 0.82 | HCAR3 (0.51) | HCAR3MAPTPKMALDH1A1NPSR1 | |
| SCHEMBL11267808 | 0.80 | HCAR3 (0.81) | HCAR3MAPTPKMPOLBALDH1A1 | |
| SCHEMBL14697877 | 0.78 | KMT2A (0.55) | HCAR3MAPTPKMPOLBALDH1A1 | |
| SCHEMBL11744600 | 0.78 | MAPT (0.64) | HCAR3MAPTPKMPOLBALDH1A1 | |
| SCHEMBL4967065 | 0.78 | MAPT (0.48) | HCAR3MAPTALDH1A1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |