Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719024 | 0.90 | HCAR3 (0.61) | HCAR3MAPTALDH1A1PKMNPC1 | |
| SCHEMBL3719487 | 0.82 | HCAR3 (0.62) | HCAR3MAPTALDH1A1PKMNPC1 | |
| SCHEMBL8111762 | 0.78 | MAPT (0.58) | MAPTALDH1A1PKMNPSR1KAT2B | |
| SCHEMBL11877200 | 0.78 | ALDH1A1 (0.57) | HCAR3MAPTALDH1A1PKMNPSR1 | |
| SCHEMBL5591726 | 0.77 | ALDH1A1 (0.50) | HCAR3MAPTALDH1A1PKMNPC1 | |
| SCHEMBL7800550 | 0.76 | HTT (0.57) | HCAR3MAPTALDH1A1PKMNPC1 | |
| SCHEMBL3721854 | 0.76 | MAPT (0.60) | HCAR3MAPTALDH1A1PKMNPC1 | |
| SCHEMBL11878741 | 0.75 | HCAR3 (0.55) | HCAR3MAPTALDH1A1RAB9ANPSR1 | |
| SCHEMBL3636228 | 0.75 | KAT2B (0.69) | HCAR3MAPTALDH1A1PKMNPC1 | |
| SCHEMBL11552885 | 0.75 | HCAR3 (0.54) | HCAR3MAPTALDH1A1PKMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |