Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.43 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.43 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | S100B | P04271 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10600686 | 0.77 | CYP2D6 (0.41) | CYP2C19CYP2D6OPRM1GRIN1KCNH2 | |
| Hydrochloric Acid SCHEMBL3725099 | 0.72 | HRH3 (0.47) | HRH3HRH4PRMT1F2ST14 | |
| SCHEMBL7147886 | 0.71 | HRH3 (0.48) | HRH3HRH4PRMT1F2ST14 | |
| Iodide SCHEMBL3719395 | 0.70 | HRH3 (0.47) | HRH3HRH4PRMT1F2ST14 | |
| SCHEMBL3744394 | 0.68 | SIGMAR1 (0.43) | CYP3A4CYP2C19HRH3HRH4PLAU | |
| SCHEMBL30514014 | 0.67 | HRH3 (0.61) | HRH3DRD3KCNH2ALDH1A1 | |
| SCHEMBL11815991 | 0.67 | HRH3 (0.61) | HRH3DRD3KCNH2ALDH1A1 | |
| SCHEMBL9770302 | 0.66 | ALDH3A1 (0.62) | HRH3DRD3KCNH2ALDH1A1 | |
| SCHEMBL3660756 | 0.66 | NAMPT (0.52) | HRH3PRMT1F2ST14PLAU | |
| SCHEMBL1820546 | 0.64 | PRMT1 (0.86) | HRH3PRMT1F2ST14PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197443-A2 | COMPOSITIONS AND METHODS FOR EFFECTING NAD+ LEVELS USING A NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE INHIBITOR | Gemin X Pharmaceuticals Canada Inc. (CA) | 2010-06-23 | — | — | EP | claimed |
| WO-2009072004-A2 | COMPOSITIONS AND METHODS FOR EFFECTING NAD+ LEVELS USING A NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE INHIBITOR | GEMIN X PHARMACEUTICALS CANADA, INC. (US) | 2009-06-11 | — | — | WO | claimed |
| EP-2197443-A2 | COMPOSITIONS AND METHODS FOR EFFECTING NAD+ LEVELS USING A NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE INHIBITOR | Gemin X Pharmaceuticals Canada Inc. (CA) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009072004-A2 | COMPOSITIONS AND METHODS FOR EFFECTING NAD+ LEVELS USING A NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE INHIBITOR | GEMIN X PHARMACEUTICALS CANADA, INC. (US) | 2009-06-11 | — | — | WO | disclosed |