Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.61 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | NPY2R | P49146 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19944672 | 0.86 | ADRB1 (0.73) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL6277059 | 0.85 | ADRB1 (0.67) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL18034999 | 0.82 | ADRB2 (0.68) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL9599229 | 0.82 | ADRB1 (0.68) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL9598039 | 0.82 | ADRB1 (0.68) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL15275621 | 0.81 | ADRB1 (0.66) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL7215333 | 0.81 | ADRB1 (0.66) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL11093561 | 0.81 | ADRB2 (0.66) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| SCHEMBL10864310 | 0.80 | ADRB2 (0.57) | ADRB1ADRB2CYP2D6NR3C1ADRA1A | |
| Hydrochloric Acid SCHEMBL10607565 | 0.80 | ADRB2 (0.64) | ADRB1ADRB2CYP2D6NR3C1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414543-B1 | GENETIC MARKERS FOR RISK MANAGEMENT OF ATRIAL FIBRILLATION AND STROKE | DECODE GENETICS EHF (IS) | 2016-10-12 | — | — | EP | disclosed |
| WO-2010113185-A1 | GENETIC MARKERS FOR RISK MANAGEMENT OF ATRIAL FIBRILLATION AND STROKE | DECODE GENETICS EHF (IS) | 2010-10-07 | — | — | WO | disclosed |