SCHEMBL3720192

SCHEMBL3720192

CC(=O)N(C)c1ccc(NC(C)C)c([N+](=O)[O-])c1

nearest known ligand 0.59

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 5/20 0.59
MAPT P10636 5/20 0.56
NPSR1 Q6W5P4 1/20 0.56
ALDH1A1 P00352 2/20 0.45
KMT2A Q03164 1/20 0.42
MAPK1 P28482 1/20 0.42
POLB P06746 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19501884 0.83 HCAR3 (0.61) HCAR3MAPTNPSR1ALDH1A1KMT2A
SCHEMBL11744600 0.82 MAPT (0.64) HCAR3MAPTNPSR1ALDH1A1KMT2A
SCHEMBL5591726 0.81 ALDH1A1 (0.50) HCAR3MAPTNPSR1ALDH1A1POLB
SCHEMBL3722356 0.79 HCAR3 (0.60) HCAR3MAPTNPSR1ALDH1A1KMT2A
SCHEMBL3719024 0.79 HCAR3 (0.61) HCAR3MAPTNPSR1ALDH1A1POLB
SCHEMBL25877600 0.79 MAPT (0.50) HCAR3MAPTNPSR1ALDH1A1MAPK1
SCHEMBL3719487 0.77 HCAR3 (0.62) HCAR3MAPTNPSR1ALDH1A1MAPK1
SCHEMBL11877200 0.77 ALDH1A1 (0.57) HCAR3MAPTNPSR1ALDH1A1POLB
SCHEMBL4967065 0.77 MAPT (0.48) HCAR3MAPTNPSR1ALDH1A1KMT2A
SCHEMBL11140206 0.77 MAPK1 (0.50) HCAR3MAPTNPSR1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010126922-A1 BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK GLAXOSMITHKLINE LLC (US) 2010-11-04 WO disclosed
WO-2010126922-A1 BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK GLAXOSMITHKLINE LLC (US) 2010-11-04 WO disclosed