Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11744600 | 0.83 | MAPT (0.64) | HCAR3MAPTNPSR1ALDH1A1MAPK1 | |
| SCHEMBL3720192 | 0.79 | HCAR3 (0.59) | HCAR3MAPTNPSR1ALDH1A1MAPK1 | |
| SCHEMBL11341363 | 0.79 | HCAR3 (0.79) | HCAR3L3MBTL1MAPTTDP1ALDH1A1 | |
| SCHEMBL3719024 | 0.77 | HCAR3 (0.61) | HCAR3MAPTNPSR1TDP1ALDH1A1 | |
| SCHEMBL109353 | 0.77 | TDP1 (0.67) | HCAR3L3MBTL1MAPTTDP1ALDH1A1 | |
| SCHEMBL2338616 | 0.75 | HCAR3 (1.00) | HCAR3L3MBTL1MAPTALDH1A1POLB | |
| SCHEMBL3719487 | 0.75 | HCAR3 (0.62) | HCAR3MAPTNPSR1TDP1ALDH1A1 | |
| SCHEMBL11877200 | 0.75 | ALDH1A1 (0.57) | HCAR3MAPTNPSR1TDP1ALDH1A1 | |
| SCHEMBL4967065 | 0.75 | MAPT (0.48) | HCAR3L3MBTL1MAPTNPSR1TDP1 | |
| SCHEMBL1437915 | 0.75 | HCAR3 (0.68) | HCAR3L3MBTL1MAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |