Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720261 | 0.81 | ACACB (0.51) | LMNAKDM4ENPC1MAPTRAB9A | |
| SCHEMBL3726761 | 0.78 | SMN1; SMN2 (0.35) | LMNAKDM4ENPC1MAPTRAB9A | |
| SCHEMBL3726759 | 0.76 | CREBBP (0.43) | LMNANPC1TP53MAPTMAOA | |
| SCHEMBL3727137 | 0.75 | GRIN2D (0.42) | LMNACYP1A2KDM4ENPC1TP53 | |
| SCHEMBL4681504 | 0.73 | PARP10 (0.56) | LMNANPC1MAPTRAB9AACACB | |
| SCHEMBL3717663 | 0.72 | GLA (0.40) | SMN1; SMN2HTR2A | |
| SCHEMBL3719224 | 0.71 | TRPV1 (0.46) | LMNAMAPTSMN1; SMN2MTNR1AACACB | |
| SCHEMBL4684155 | 0.69 | ALDH1A1 (0.50) | LMNACYP1A2CYP3A4MAPTSMN1; SMN2 | |
| SCHEMBL1285452 | 0.68 | CYP1A2 (0.75) | CYP1A2CYP3A4MTNR1A | |
| SCHEMBL4854939 | 0.68 | HDAC1 (0.59) | LMNACYP1A2KDM4ENPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |