Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 2/20 | 0.38 |
| ▸ | SKP1 | P63208 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817445 | 0.82 | ADORA1 (0.42) | NR1H2HTTATMCKS1BSKP1 | |
| SCHEMBL2811786 | 0.82 | GPR119 (0.47) | CKS1BSKP1SKP2ACHEMAPK1 | |
| SCHEMBL5935830 | 0.81 | P2RX7 (0.53) | NR1H2HTTATMESR2MAPT | |
| SCHEMBL15933470 | 0.81 | NR1H2 (0.41) | NR1H2HTTATMCKS1BSKP1 | |
| SCHEMBL14553991 | 0.80 | MGLL (0.43) | NR1H2HTTATMCKS1BSKP1 | |
| SCHEMBL29697704 | 0.79 | NR1H2 (0.40) | NR1H2HTTATMCKS1BSKP1 | |
| SCHEMBL2753515 | 0.79 | NR1H2 (0.40) | NR1H2HTTATMCKS1BSKP1 | |
| SCHEMBL15882223 | 0.79 | NR1H2 (0.40) | NR1H2HTTATMCKS1BSKP1 | |
| SCHEMBL25431198 | 0.78 | GPR119 (0.45) | NR1H2HTTATMESR2GPR119 | |
| SCHEMBL19609080 | 0.78 | NR1H2 (0.50) | NR1H2HTTATMESR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393812-B1 | SUBSTITUTED SPIROAMIDES AS B1R-MODULATORS | GRUENENTHAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2393812-A1 | SUBSTITUTED SPIRO-AMIDES AS B1R MODULATORS | Grünenthal GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089127-A1 | SUBSTITUTED SPIRO-AMIDES AS B1R MODULATORS | Grünenthal GmbH (DE) | 2010-08-12 | — | — | WO | disclosed |