Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.42 |
| ▸ | ESR1 | P03372 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16411283 | 0.92 | S1PR1 (0.47) | S1PR1ESR2ESR1CYP3A4CYP2C9 | |
| SCHEMBL6884915 | 0.90 | S1PR1 (0.52) | S1PR1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL28188626 | 0.87 | MEN1 (0.46) | S1PR1ESR2ESR1CYP3A4CYP2C9 | |
| SCHEMBL21309864 | 0.79 | ACHE (0.39) | CYP2C9MEN1ALDH1A1MAPTKMT2A | |
| Phenol SCHEMBL28188627 | 0.79 | CARM1 (0.48) | S1PR1CYP3A4CYP2C9MEN1ALDH1A1 | |
| SCHEMBL10398544 | 0.79 | NPC1 (0.41) | L3MBTL1MEN1ALDH1A1POLBMAPT | |
| SCHEMBL25330831 | 0.78 | JAK2 (0.45) | ALDH1A1POLBMAPK1KDM4ECARM1 | |
| SCHEMBL2935193 | 0.78 | PTGER4 (0.42) | CYP3A4CYP2C9L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL3717751 | 0.78 | RAB9A (0.44) | L3MBTL1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL10187375 | 0.78 | PTGER4 (0.42) | CYP3A4CYP2C9L3MBTL1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240245699-A1 | PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2024-07-25 | — | — | US | disclosed |
| US-20210290631-A1 | PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2021-09-23 | — | — | US | disclosed |
| US-11058689-B2 | Pyrrole compounds, a process for their preparation and pharmaceutical | LES LABORATOIRES SERVIER (FR) | 2021-07-13 | — | — | US | disclosed |
| US-20200261464-A1 | PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2020-08-20 | — | — | US | disclosed |
| US-10688101-B2 | Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATORIES SERVIER (FR) | 2020-06-23 | — | — | US | disclosed |
| US-10662173-B2 | Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2020-05-26 | — | — | US | disclosed |
| US-10414754-B2 | Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2019-09-17 | — | — | US | disclosed |
| US-20190192528-A1 | PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2019-06-27 | — | — | US | disclosed |
| US-10265323-B2 | Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2019-04-23 | — | — | US | disclosed |
| US-10258626-B2 | Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATORIES SERVIER (FR) | 2019-04-16 | — | — | US | disclosed |
| US-20150051189-A1 | INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | VERNALIS (R&D) LTD (GB) | 2015-02-19 | — | — | US | disclosed |
| US-20150031648-A1 | PHOSPHATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2015-01-29 | — | — | US | disclosed |
| WO-2015011397-A1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2015-01-29 | — | — | WO | disclosed |
| WO-2015011400-A1 | NOVEL PYRROLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2015-01-29 | — | — | WO | disclosed |
| US-20150031673-A1 | PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2015-01-29 | — | — | US | disclosed |
| WO-2015011396-A1 | NOVEL DERIVATIVES OF INDOLE AND PYRROLE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2015-01-29 | — | — | WO | disclosed |
| EP-2829545-A1 | New phosphate derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2015-01-28 | — | — | EP | disclosed |
| EP-2829539-A1 | New pyrrole derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2015-01-28 | — | — | EP | disclosed |
| CN-104144930-A | New indolizine derivatives, method for preparing same and pharmaceutical compositions containing same | SERVIER LAB | 2014-11-12 | — | — | CN | disclosed |
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662173-B2 | Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them | RB1, IDO1, BCL2A1 | S1PR1 454/4885ESR2 2212/4885ESR1 2867/4885 |
| US-11058689-B2 | Pyrrole compounds, a process for their preparation and pharmaceutical | PDCD11, RRM2B, RRS1 | S1PR1 353/4885ESR2 1536/4885ESR1 1668/4885 |
| US-20210290631-A1 | PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PDCD11, RRM2, RRM2B | S1PR1 501/4885ESR2 1696/4885ESR1 1470/4885 |
| US-20150031673-A1 | PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PDCD11, RRM2B, RRM2 | S1PR1 591/4885ESR2 1447/4885ESR1 1967/4885 |
| US-20200261464-A1 | PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PDCD11, RRS1, RRM2B | S1PR1 527/4885ESR2 1459/4885ESR1 2035/4885 |
| US-10258626-B2 | Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | IDO1, IDO2, API5 | S1PR1 1149/4885ESR2 978/4885ESR1 670/4885 |
| US-10414754-B2 | Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | IDO1, API5, IDO2 | S1PR1 1643/4885ESR2 1119/4885ESR1 777/4885 |
| US-20240245699-A1 | PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PDCD11, RRM2B, RRM2 | S1PR1 591/4885ESR2 1447/4885ESR1 1967/4885 |
| US-10688101-B2 | Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them | PDCD11, RRM2B, RRM2 | S1PR1 591/4885ESR2 1447/4885ESR1 1967/4885 |
| US-20150051189-A1 | INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IDO1, IDO2, API5 | S1PR1 1149/4885ESR2 978/4885ESR1 670/4885 |
| US-20190192528-A1 | PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PDCD11, RRM2B, RRM2 | S1PR1 591/4885ESR2 1447/4885ESR1 1967/4885 |
| US-20150031648-A1 | PHOSPHATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ENPP2, RB1, RRM2 | S1PR1 240/4885ESR2 1209/4885ESR1 2302/4885 |
| US-10265323-B2 | Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them | PDCD11, RRM2B, RRM2 | S1PR1 591/4885ESR2 1447/4885ESR1 1967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.