Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717907 | 0.78 | CLK4 (0.52) | HPGDALDH1A1ADORA3ADORA1NPC1 | |
| SCHEMBL3725579 | 0.78 | DYRK1A (0.65) | ALDH1A1ADORA3ADORA1NPC1MAPT | |
| SCHEMBL3723906 | 0.78 | PTGS2 (0.51) | HPGDALDH1A1ADORA3ADORA1NPC1 | |
| SCHEMBL10201448 | 0.77 | LMNA (0.49) | ALDH1A1MAPT | |
| SCHEMBL12128814 | 0.77 | HPGD (0.61) | HPGDALDH1A1NPC1MAPTPKM | |
| SCHEMBL4043093 | 0.73 | FLT3 (0.48) | HPGDALDH1A1NPC1MAPTPKM | |
| SCHEMBL3724659 | 0.72 | DYRK1A (0.51) | ADORA3ADORA1EPHB4NPC1MAPT | |
| SCHEMBL13032122 | 0.71 | JAK2 (0.58) | HPGD | |
| SCHEMBL14021573 | 0.69 | HTT (0.56) | ALDH1A1MAPTPKMRAB9AKDM4E | |
| SCHEMBL3723229 | 0.69 | ADORA1 (0.48) | HPGDALDH1A1ADORA3ADORA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |